This alignment was performed with the Multalin service of the Network Protein Sequence @nalysis, provided by Pole Bio-Informatique Lyonnaise
10 20 30 40 50 60
| | | | | |
aTTP_32kDa ------------------------------------------MAEARSQPSAGPQLNALP
CRAL_human MSEGVGTFRMVPEEEQELRAQLEQLTTKDHGPVFGPCSQLPRHTLQKAKDELNEREETRE
TAP_45kDa -------------------------------------------------------MSGRV
PTPASE_MEG2 ---------------------------------------------MEPATAP---RPDMA
Sec14p -------------------------------------QQEKEFLESYPQNCPPDALPGTP
Consensus
Prim.cons. MSEGVGTFRMVPEEEQELRAQLEQLTTKDHGPVFGPC2Q22233E44PQ44P333LPGRP
70 80 90 100 110 120
| | | | | |
aTTP_32kDa DHSPLLQPGLAALRRRAREAGVPLAPL--PLTDSFLLRFLRARDFDLDLAWRLLKNYYKW
CRALBP_human EAVRELQEMVQAQAASGEELAVAVAERVQEKDSGFFLRFIRARKFNVGRAYELLRGYVNF
TAP_45kDa GDLSPRQKEALAKFRENVQD-V-LPALPNPDDYFL-LRWLRARSFDLQKSEAMLRKHVEF
PTPASE_MEG2 PELTPEEEQATKQFLEEINKWT-VQYNVSPLSWNVAVKFLMARKFDVLRAIELFHSYRET
Sec14p GNLDSAQEKALAELRKLLED----AGFIERLDDSTLLRFLRARKFDVQLAKEMFENCEKW
Consensus l #e a a r # v a pld lrflrARkF#v a e$l y
Prim.cons. G5L5PLQE5ALAQFRE55ED3V22A5LV4PLDDSFLLRFLRARKFDVQ2A5ELLRNYV22
130 140 150 160 170 180
| | | | | |
aTTP_32kDa RAEC-------------PEISADLHPRSIIGLLKAGYHGVLRSRDPTGSKVLIYRIAHWD
CRALBP_human RLQY-------------PELFDSLSPEAVRCTIEAGYPGVLSSRDKYGRVVMLFNIENWQ
TAP_45kDa RKQKDIDNIIS---WQPPEVIQQYLSGGMCGYDLDGCPVWYDIIGPLDAKGLLFSASKQD
PTPASE_MEG2 RRKEGIVKLKP---HEEP-LRSEILSGKF---------TILNVRDPTGASIALFTARLHH
Sec14p RKDYGTDTILQDFHYDEKPLIAKFYPQYYHKTDKDGRPVYFEELGAVNLHEMNKVTSEER
Consensus R pel p g p l rdp g lf
Prim.cons. RKQYGID3I33DFH33EPELIA5LLPG554GTDK2GYP2VL5SRDPTGAKV2LF52S5WD
190 200 210 220 230 240
| | | | | |
aTTP_32kDa PKVFTAYDVFRVSLITSELIVQEVETQRNGIKAIFDLEGWQFSHAFQITPSVAKKIAAVL
CRALBP_human SQEITFDEILQAYCFILEKLLENEETQINGFCIIENFKGFTMQQAASLRTSDLRKMVDML
TAP_45kDa LLRTKMREC-ELLLQECAHQTTKLGRKVETITIIYDCEGLGLKHLWKPAVEAYGEFLCMF
PTPASE_MEG2 PHKSVQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNYANF---ELDLGKKVLNLL
Sec14p MLKNLVWEYESVVQYRLPACSRAAGHLVETSCTIMDLKGISISSAYS-VMSYVREASYIS
Consensus e l etq #g I # G a s k l
Prim.cons. PLK5T55EVLQ2LLY5LE55V555ETQ2NGICIIYDL2G555SHA4S355S552K5L5ML
250 260 270 280 290 300
| | | | | |
aTTP_32kDa TDSFPLKVRGIHLINEPVIFHAVFSMIKPFLTEKIKERIHMHGNNYKQSLLQHFP-DILP
CRALBP_human QDSFPARFKAIHFIHQPWYFTTTYNVVKPFLKSKLLERVFVHGDDLSGFYQEIDE-NILP
TAP_45kDa EENYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIMVLGANWKEVLLKHISPDQVP
PTPASE_MEG2 KGAFPARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERIQILKTS---EVTQHLPRECLP
Sec14p QNYYPERMGKFYIINAPFGFSTAFRLFKPFLDPVTVSKIFILGSSYQKELLKQIPAENLP
Consensus %P r k ! aP F % ikpfL k er! lg ll h p # lP
Prim.cons. QDSFP2RLKKIHIINAP55F52AY2LIKPFLKEKTRERIF2LG52YK4ELL2HIP32ILP
310 320 330 340 350 360
| | | | | |
aTTP_32kDa LEYGG--EEFSMEDICQEWTNFIMKSEDYLSSISESIQ----------------------
CRALBP_human SDFGG--TLPKYDGKAVAEQLFGPQAQAENTAF---------------------------
TAP_45kDa VEYGGTMTDP--DGNPKCKSKINYGGDIPRKYYVRDQVKQQYEHSVQISRGSSHQVEYEI
PTPASE_MEG2 ENLGGYVKIDLATWNFQFLPQVNGHPDPFDEIILFSLPPALDWDSVHVPGPHAMTIQELV
Sec14p VKFGGKSEVDESKGGL-YLSDIGPWRDPKYIGPEGEAPE---------------------
Consensus GG g #
Prim.cons. VE2GG3325244DGN5Q5LS522P55DP5555I44S4P322222SV22222222222222
370 380 390 400 410 420
| | | | | |
aTTP_32kDa ------------------------------------------------------------
CRALBP_human ------------------------------------------------------------
TAP_45kDa LFPGCVLRWQFMSDGADVG----FGIFLKTKMGERQRAGEMTEVLPNQRYNSHLVPEDG-
PTPASE_MEG2 DYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGH
Sec14p ------------------------------------------------------------
Consensus
Prim.cons. 2222222222222222D22RENP2G2F2222222222222222V222222222L2222GH
430 440 450 460 470 480
| | | | | |
aTTP_32kDa ------------------------------------------------------------
CRALBP_human ------------------------------------------------------------
TAP_45kDa TLTCSDPGIYVLRFDNTYSFIHAKKVNFTVEVLLPDKASEEKMKQLGAGTPK--------
PTPASE_MEG2 TQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKC
Sec14p ------------------------------------------------------------
Consensus
Prim.cons. T2T22222222222222222I222222222222222222E2K2222222T22EEGGRRKC
490 500 510 520 530 540
| | | | | |
aTTP_32kDa ------------------------------------------------------------
CRALBP_human ------------------------------------------------------------
TAP_45kDa ------------------------------------------------------------
PTPASE_MEG2 GQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYG
Sec14p ------------------------------------------------------------
Consensus
Prim.cons. GQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYG
550 560 570 580 590 600
| | | | | |
aTTP_32kDa ------------------------------------------------------------
CRALBP_human ------------------------------------------------------------
TAP_45kDa ------------------------------------------------------------
PTPASE_MEG2 VPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICL
Sec14p ------------------------------------------------------------
Consensus
Prim.cons. VPSSAASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICL
610 620 630 640 650 660
| | | | | |
aTTP_32kDa ------------------------------------------------------------
CRALBP_human ------------------------------------------------------------
TAP_45kDa ------------------------------------------------------------
PTPASE_MEG2 AQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVES
Sec14p ------------------------------------------------------------
Consensus
Prim.cons. AQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVES
aTTP_32kDa -
CRALBP_human -
TAP_45kDa -
PTPASE_MEG2 Q
Sec14p -
Consensus
Prim.cons. Q