MSc/PhD Position in Bioorganic-Synthetic Organic Chemistry

ORGANIC SYNTHESIS OF TOCOPHEROLS

The synthetic position will have the goals of preparing selectively deuterated tocopherols and associated compounds, fluorescent tocopherols as ligands for lipid transfer and protein binding assays, and assorted affinity ligands for modeification of proteins and membrane constitutents by tocopherols.

There is plenty of information flow within the project - from the bench, through assays and back again - both within our own group and with excellent collaborating colleagues in North America and Europe.  This is an excellent project for anyone looking for a topic in bioorganic chemistry.

Applicants should have achieved demonstrable success in organic chemistry and synthesis at the undergraduate level. While experience in biochemistry is not an absolute requirement, a willingness to work at the interface between organic chemistry, medicinal and biological chemistry is a definite asset.

This is a hybrid research environment that offers a student experience in topics and techniques that are uniquely portable to the pharmaceutical, biotechnological, and health science industries.
 
 
 

MSc/PhD/Postdoctoral Position in Lipid Transfer Proteins

LIPID TRANSFER PROTEIN BIOCHEMISTRY

This position will be dedicated to using the fluorescent ligands that we have created to investigate the mechanisms of action of proteins involved in the transfer of tocopherol between membranes.  A new PTI QuantaMaster Fluorometer purchased from monies recevied from the Candian Foundation for Innovation is equipped with a stopped flow device and sundry other goodies to enable a thorough charcterization of the kinetics of ligand transfer between vesicles and proteins as models for in vivo membrane transfer.

Applicants would do well to have experience in handling recombinant proteins (including expresion systems, but this is not essential), and be familair with some aspects of fluorescence spectroscopy and basic kinetics.

Brock University is located in St. Catharines, Ontario, in the Niagara Peninsula, one of the premier wine producing regions of Canada. We are 40 minutes from Buffalo and one hour from Toronto. The Department of Chemistry is well equiped with a brand new 300 MHz Bruker DPX NMR, Kratos Mach 3 mass spectrometer, UV, IR and fluorescence spectrophotometers, several HPLCs, Silicon Graphics workstations and much more.
 
 

Intersted candidates should contact me at the address shown below.